ABOUT

Azalée is a French company, founded in 2012, which develops an innovative technology for assessing the characteristics of the cortical bone

The VOG* (Vitesse des Ondes Guidées) technology is based on the measurement of ultrasonic guided modes in the cortical part of the bone that behaves as a waveguide.

It allows non-invasive measurement of cortical thickness and porosity in the arm (radius) and leg (tibia).
Azalée is the result of the work of the Biomedical Imaging Laboratory (INSERM CNRS/Université Pierre et Marie Curie) which conducts fundamental and applied research on morphological, functional and molecular biomedical imaging methods on small animals and humans.

Azalée is a subsidiary of Quattrocento, a company builder specialising in life sciences equipment.

*VOG technology is protected by 3 patent families

An innovative method for assessing the characteristics of cortical bone

Quantitative

Non invasive

Fast

Reproducible

Portable

TECHNOLOGY

The VOG technology is the result of research by Professor Pascal Laugier, Jean-Gabriel Minonzio, Emmanuel Bossy and Maryline Talmant, specialists in ultrasound for bone. The measurement takes place in 3 steps.

A dedicated, multi-transmitter probe is used to generate ultrasonic waves in the cortical bone at the radius and tibia region.
Probe receivers retrieve modes guided by the cortical part of the bone.

A processing algorithm (based on singular values decomposition) has been developed to analyze the 5*24 acquisitions (5 transmitters, 24 receivers) to obtain the complete spectral image of the cortical bone.

The experimental data are then compared with a database of models. The one with the strongest correlation to measurement provides mechanical bio-markers of the bone, including cortical thickness and porosity.

The bone model developed in the laboratory has already made it possible to measure 2 relevant parameters of cortical bone, while the spectral image opens up new perspectives for analysis

Thickness

Porosity

Discoveries

PAPERS

In vivo measurement at radius

Q. Vallet, N. Bochud, C. Chappard, P.
Laugier, and J.-G. Minonzio, «In-vivo cortical bone characterization using guided waves measured by axial transmission,» IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 63 1361 – 1371 (2016).

Reverse problem, genetic algorithms

N. Bochud, Q. Vallet, T. Bala, H. Follet, J.-G. Minonzio, and P. Laugier, “Genetic algorithms- based inversion of multimode guided waves for cortical bone characterization», Phys. Med. Biol. 61, 6953 – 6974 (2016).

Correction for attenuation

J.-G. Minonzio, J. Foiret, M. Talmant, P. Laugier, “Impact of attenuation on guided mode wavenumber measurement in axial transmission on bone mimicking plates,” J. Acoust. Soc. Am. 130, 3574-3582 (2011).

Mode measurement using SVD-based method

J.-G. Minonzio, M. Talmant, and P. Laugier, “Guided wave phase velocity measurement using multi-emitter and multi-receiver arrays in the axial transmission configuration,” J. Acoust. Soc. Am. 127, 2913-2919 (2010).

Ex vivo measurement

J. Foiret, J.-G. Minonzio, Ch. Chappard , M. Talmant, and P. Laugier, “Combined estimation of thickness and velocities using ultrasound guided waves : a feasibility study on in vitro cortical bone samples,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 61, 1478-1488 (2014).

Two-layer model

N. Bochud, Q. Vallet, J.-G. Minonzio, and
P. Laugier, «Predicting bone strength with ultrasonic guided waves» Scientific Reports 7, 43628 (2017).

Bi-directionnal correction

L. Moreau , J.-G. Minonzio, J. Foiret , E. Bossy , M. Talmant, and P. Laugier, « Accurate measurement of guided modes in a plate using a bidirectional approach, » J. Acoust. Soc. Am. 135, EL15-EL21 (2014).

Correction for thickness variation

L. Moreau, J.-G. Minonzio, M. Talmant, and P. Laugier, « Measuring the wavenumber of guided modes in a thickness-varying waveguide, » J. Acoust. Soc. Am. 135, 2614 – 2625 (2014).

RESEARCH TEAM

Pr Pascal Laugier
CNRS Research Director, LIB Director

Jean-Gabriel Minonzio
CNRS Researcher, LIB

Emmanuel Bossy
Professor, LIPHY, Grenoble University

Maryline Talmant
CNRS Researcher, LIB

APPLICATIONS

Osteoporosis
VOG technology is particularly well suited for clinical studies in osteoporosis.
A pilot trial, currently being published and aimed at predicting fracture risk, was conducted on 299 postmenopausal patients in the rheumatology department of Cochin Hospital.

Paediatrics
VOG technology, which is non-irradiating and non-invasive, is the ideal tool for monitoring bones in children, and a pilot trial is ongoing with the Paediatrics Department of the Trousseau Hospital for the follow-up of myopathic children.

Monitoring
VOG technology is particularly suitable for monitoring the effects of cortical bone altering therapies such as long term corticosteroids or hormone therapies.

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